Cyrus Renault is a fictional character and a main antagonist on the ABC soap opera General Hospital.
He bore an uncanny resemblance to the late Cesar Faison before changing his appearance on August 22, 2023 looking less like Faison and beginning to look like Johnny Zacchara 25-30 years later as well as to bore an uncanny resemblance to the late Victor Cassadine before dropping off the canvas on April 18, 2024. He is also the brother of attorney Martin Grey, the son of Florence Grey, and the father of Andrew and Liz Grey.
He returned on June 29, 2023 after The Hook attacks, the death and memorial service of Epiphany Johnson, Linc Brown's arrest, and the death of Victor Cassadine via drone strike to The Haunted Star by the WSB.
He was last seen on April 18, 2024 before dropping off the canvas going offscreen and later since replaced by Charles Mesure as Jack Brennan, Adam J. Harrington as FBI agent John Cates previously Jagger Cates before the character's death, Virginia Ma as Madison Yeung, and Dieterich Gray as Adrian DeWitt.
He returned on August 20, a day after Parry Shen returned as Brad Cooper before the returns of Rick Hearst as Ric Lansing two days later on August 22 and Jonathan Jackson as Lucky Spencer a day after that on August 23 after four months.
He returned on November 20, 2024.
Casting[]
On January 31, 2020; Soaps.com and other sources confirmed that actor Jeff Kober, known for appearing in NCIS: Los Angeles, The Walking Dead, Sons of Anarchy, and Falcon Crest, would join the cast of GH in the role of Cyrus Renault.
He made his first appearance at the end of the episode on February 5, 2020.
The role was initially supposed to last only a few months, however executive producer Frank Valentini told Kober that he would continue writing for the character as long as Kober was enjoying himself.
On June 16, 2021; it was revealed that Kober is done as Cyrus and has exited GH. He made his last appearance on June 16, 2021.
On June 18, 2021; Kober revealed on the "Dishing with Digest" podcast that he enjoyed his time on the show and is open to returning as Cyrus on GH again.
Kober made a short return from August 31 to September 1, 2021. He made another short return on October 28 and November 3, 2021. He returned yet again on November 30 and December 20, 2021.
On May 12, 2022; Kober was seen back in the GH studio when GH celebrated their 15,000th episode. He returned for one episode on June 22, 2022 as part of the 15,000th episode.
Kober returned as Cyrus for a total of seven episodes which aired from October 3 to December 28, 2022.
On October 28, 2022; Kober opened up about his return to GH and revealed that he'll film at least three more episodes after he returns from Texas and will be replaced by an unknown actor as The Hook concealing her face and identity, Charles Shaughnessy as Victor Cassadine, and Dan Buran as Linc Brown.
Kober returned as Cyrus on June 29, 2023 after The Hook attacks which lead to Heather Webber's arrest, Linc Brown's arrest after the death of Epiphany Johnson, and the death and will reading of Victor Cassadine. Kober was last seen on April 18, 2024 as he was filming the movie "Grassland" before later replaced by Cameron Mathison as Drew Cain, Adam J. Harrington as FBI Special Agent John Cates (previously Jagger Cates), and Charles Mesure as Jack Brennan. On June 17, 2024, Kober revealed on his Instagram he had wrapped filming.
Kober returned as Cyrus on August 20, 2024 a day after Parry Shen returned as Brad Cooper a year and five months later, then Rick Hearst as Ric Lansing two days later on August 22 when the actor returned to California, and Jonathan Jackson as Lucky Spencer a day later on August 23.
Coby Ryan McLaughlin who previously portrayed as Hank Archer aka "Shiloh" will return and portray as Cyrus Renault in his younger days.
Storylines[]
On January 7, 2020; Sonny Corinthos learned from Gio, an employee of his, that a truck had been hijacked. Sonny made it clear that he didn't want to deal with those people since he wanted the Port Charles Police Department to know he was a legitimate businessman since all they would find in that truck is coffee. A few days later, it was later revealed that the truck had been found, abandoned, and torched after Hayden Barnes left Port Charles again and was nowhere to be found and Margaux Dawson resigned as district attorney and left town.
On February 4, Cyrus is first mentioned. Sonny questions the captured gunman and then Sonny allows Brent to beat up the gunman after he won't say who he is working for. Later Jason walks by and sees that Brent has been shot and killed. Jason is also shot at by the escaped gunman and they fire at each other. One of Jason's bullets hits the gunman and Jason asks the gunman to tell him who he works for since he is dying. The gunman says "Cyrus Renault" and Jason has a worried look on his face after Drew Cain's presumed death.
On February 5, 2020; Jason tells Sonny and Carly that the gunman said he was working for Cyrus Renault, a drug runner who normally operates in the Pacific Northwest. Cyrus has been operating from Thompson Penitentiary for the last ten years but Brick discovered that Cyrus was secretly transferred to Pentonville Penitentiary recently where Hank Archer aka Shiloh, Sam McCall, his female counterpart Cassandra Pierce, and his henchwoman Nelle Benson were at and currently where serial killers Ryan Chamberlain and Cyrus' cellmate Paul Hornsby are at. Sonny said he has never dealt with Cyrus and only knows him by reputation. Later, Sonny stops by Pentonville to visit Cyrus.
On April 6, Cyrus was released from Pentonville with a full exoneration and is an attempt to replace Sam McCall as Cyrus gained new allies and friends like the Attorney General and Gabriel Burke. Leaving his friend Paul all by himself until Brad Cooper became Paul's new cellmate.
On April 23, Cyrus gets interviewed by Lulu Spencer from The Invader tabloid while he's doing good at keeping Jason and Sam apart.
On April 27-28, Cyrus and Franco were seen on Pier 55 during a meeting with Sonny and Jason. Jason and Franco almost start fighting a few times but Cyrus holds back Franco. Cyrus and Franco are next seen at the Metro Court Hotel together.
On May 15, Cyrus' henchwoman Nelle blackmailed Julian Jerome into marrying her into marrying her.
On the week of August 3, Cyrus talked with Portia at GH and referred to Trina. Laura stepped up to defend Portia. She later saw Cyrus talking to Tom, a GH board member. Tom ignored Laura’s insistence that Cyrus is a criminal and he quickly walked away from her. Laura asked why Cyrus was interested in the hospital. He said that he heard GH was facing a fiscal crisis and he had already established the Cyrus Renault Foundation for Social Justice, but everyone rejected the idea including General Hospital Chief of Staff Monica Quartermaine much as to Sonny and Jason's dismay. Laura told him that the money needed will come from ELQ.
On August 11, his friend/henchwoman Dolores Maloney was no longer Sam's parole officer as Owen Anderson became Sam's new parole officer who was much friendlier than Dolores and has a disdain of Cyrus Renault. However, on August 13, due to Cyrus's contribution, he became Chairman of the Board at the hospital because of Valentin Cassadine becoming the new CEO of ELQ who had secretly bought up 50% of their shares and decided to stop funding the hospital.
On August 19, Cyrus makes his first appearance at the Nurses' Ball for the first time after becoming the chairman of the board at General Hospital and is the only time to make an appearance since he bores an uncanny resemblance to Cesar Faison.
On September 3, Cyrus has Monica Quartermaine and Bobbie Spencer fired from the hospital due to the lawsuit involving lost paperwork for Wiley Quartermaine-Corinthos' surgery in revenge for Nelle Benson and Dolores Maloney.
Afterwards, his appoints Britt Westbourne as the new Chief of Staff and adopts her as his daughter after the death of her biological father Cesar Faison over two years ago and the imprisonment of her biological mother Liesl Obrecht. He also appointed Cassandra Bryant as the new Head Nurse.
Unbeknownst, there was his own two children Andrew and Liz.
On June 4, Cyrus was arrested. His children Andrew and Liz celebrated along with the PCPD officer Elisha Adams and Ellen Scully.
On August 31, Cyrus was questioned about Liesl Obrecht's disappearance. Cyrus knew that he wanted to get back at her for being threatened behind his back, but he denied any involvement in her disappearance and had an alibi. His alibi was confirmed.
On October 22, his former accomplice and associate Peter August was arrested on Cassadine Island.
On November 3, Cyrus was visited by Sonny. One week later, his friend and music producer Linc Brown returned to Port Charles after Drew was revealed to be alive. Then his enemy Drew Cain returned to Port Charles and went to Sam's apartment after getting cleaned up and shaved two weeks later.
On November 30; Cyrus called Sonny from Flatland on a cell phone he acquired from some of his contacts after Drew Cain and Liesl Obrecht have returned Port Charles, Peter August's arrest, and over two weeks after Linc Brown left The Savoy. Cyrus revealed that he still has some contacts and he went to "offer his condolences" because he heard about Jason being presumed dead on Cassadine Island after a shootout with Peter August who was in revenge for his later father Cesar Faison, Nelle Benson, and Cyrus himself.
On December 20, Laura visited Cyrus in Flatland and Cyrus was happy to see her. Laura told Cyrus that she's not running anymore and won't let him keep her from her family for one more minute. Cyrus asked if she'd been away and Laura said that a hit-woman was sent to kill both her and Martin at a safehouse plus Martin had been strangled. Cyrus appeared to be concerned and asked if Martin was okay. Laura said that Martin was fine and Cyrus seemed to be relieved. Laura wasn't happy that Cyrus was acting innocent, but Cyrus revealed that he didn't try to have her and Martin killed.
Cyrus said that he deserved Laura's anger and mistrust since he was on a dark path and he had a lot to atone for unlike the now deceased Cesar Faison. When Laura asked what he was talking about, Cyrus revealed that his life is no longer his own and he gave it to a higher power, which made Laura laugh and Cyrus smile. Laura was skeptical but Cyrus revealed that he got sick with a cold which turned into pneumonia and said that while at first the guards ignored him, they later treated him when he had a fever. Cyrus revealed that when he was in pain, he begged for help and an angel came to him, which gave him peace and when he woke up, his fever was gone. Cyrus then asked for a Bible and began to study it, so his life now belongs to God.
Laura didn't believe Cyrus and went to leave, but Cyrus stopped her and warned her that she's in danger. Laura sat back down and said that they were in familiar territory, but Cyrus said that if she focused on him then that would leave room for her real adversary to strike. Laura wondered about Sonny and Mr. Buscema since they previously came to visit him and Cyrus said that he felt a pull to his old life but he chose the light. Laura didn't believe that Cyrus had found God since she believed he was incapable of love and caring about anyone other than himself but Cyrus disagreed with her and said he would pray for her. Cyrus warned her to keep an eye on the serpent in the garden and promised her that he didn't hire anyone to kill her and Martin.
Meanwhile, it was revealed that the hit-woman who was sent to the safe-house was not working for Cyrus, she was actually working for Victor Cassadine, who was recently revealed to be alive after having thought to have been killed in 2014. It was revealed that Victor (not Cyrus) had been targeting them and he sent the hit-woman to make an attempt to kill Laura and Martin in order to draw them out of hiding.
On October 3, Cyrus found his great-nephew Spencer Cassadine almost being attacked by a Pentonville inmate named Steve Book and he stepped in to save him since his former henchwoman Sienna Colby is now working with Grant Smoltz. After Cyrus quoted the Bible to Book about punishment for those who commit violence, Book told Spencer that he got lucky this time but they won't be interrupted next time. After Steve left, Spencer told Cyrus that he had things under control but Cyrus said it didn't look like it from where he stood. When Spencer asked Cyrus what he owed him for the save, Cyrus said he wanted nothing since they're family and he would have stepped in to save any fellow child of God.
Spencer didn't trust Cyrus, but Cyrus assured Spencer that he had nothing to fear from him. Cyrus revealed to Spencer that word was out in Pentonville that he has protection but there were some inmates like Steve Book who didn't care since they had nothing to lose including Hilda Dorsey who was onto Alexis a year earlier. When Cyrus revealed that he had ways of dealing with people like that, Spencer jokingly asked "Baptism?". Cyrus told Spencer that Pentonville was dangerous and he needs protection so he promised Spencer he was there for him. Cyrus also told Spencer that all he had to do was call.
Victor then came to the prison library and Spencer was surprised to see him. Cyrus went to leave Spencer and Victor to visit, but Victor told Cyrus to stay and said he has news on Spencer's future. Cyrus was later replaced by Drew Cain, The Hook who was later revealed to be Heather Webber, and Linc Brown as Cyrus denied any involvement in the Hook attacks as he had an alibi which confirmed it.
On April 6; his friend Linc was arrested at The Nurses' Ball by Det. Dante Falconeri for his predatory behavior, identity theft, complicity, and his collusion with Dolores Maloney, Cyrus Renault, Victor Cassadine, and The Hook.
On June 29; Cyrus will be meeting Drew Cain for the first time in person at Pentonville as he says that he knows him after The Hook attacks, Linc's arrest, and Victor's death via drone strike to The Haunted Star by the WSB.
On July 3, Cyrus meets Drew Cain for the first time in person at Pentonville giving the fact that Drew had been missing in action.
Later on after Dr. Austin Gatlin-Holt checked Cyrus' vitals and all, Cyrus grabbed his wrist and cryptically revealed that he knows about his family.
On August 21 back in Pentonville, Cyrus saw that Drew was out of solitary and said how he wouldn't forget that he saved his life. When Cyrus said he owed Drew, Drew said he owed him nothing but Cyrus swore on his Bible that he'd find a way to repay him for everything.
Later on; Cyrus went to the shower room and thanked God as he showered and gave himself a clean shave and a haircut to make him look less like Faison and more like fellow inmate Johnny Zacchara 25-30 years later as well as to bore an uncanny resemblance to the late Victor Cassadine before meeting with Austin revealing that he's the mysterious boss who Austin and his cousin Mason Gatlin work for.
On October 13, Cyrus was released from prison and is driven to freedom leaving Drew Cain stay in Cyrus' place as Drew later became Johnny Zacchara's new cellmate as Cyrus is now ready for revenge for Dr. Damon Montague after Dr. Montague's arrest.
On February 2, Cyrus heard the news of his great nephew Spencer about what happened in France before his nephew Nikolas returned with Ace after Esme's presumed death.
On February 5, his nephew Nikolas was arrested knowing that he was a wanted fugitive after he and Ace returned.
Two days later on February 7, he attends his great nephew Spencer's memorial service after FBI agent John Cates previously Jagger Cates returned to Port Charles 16 years later.
On April 18; Cyrus was last seen before being since replaced by Jack Brennan, FBI agent John Cates, Madison Yeung, and associate publisher of The Invader Adrian DeWitt who later becomes acting Editor-in-Chief.
On August 20, Cyrus was visiting his hospitalized niece Lulu at Silver Water Aftercare when Kevin and Laura are about to visit her.
Now a free man, Cyrus spends his time preaching the Lord's word and offering prayers for sick patients, although many citizens of Port Charles remain unconvinced of his reformation.
On September 19, Cyrus came to General Hospital as he visited Lulu again. He also visited Isaiah Gannon as they talked about the NFL as revealing that Cyrus is a fan of the Seattle Seahawks before the death of Sam McCall a month later on October 30 and later replaced by her new enemy warlord Jenz Sidwell who became a wanted fugitive for blowing up the warehouse with a bomb on November 8 which made Sonny Corinthos furious.
On November 20, Cyrus came to the hospital room with his niece Lulu Spencer after waking up after the memorial service of the late Sam McCall.
On December 9, a flashback reveals that Cyrus delivered the fatal overdose of digitalis to Sam McCall's IV; killing her in revenge for the late Cesar Faison, the late Hank Archer aka "Shiloh", the late Cassandra Pierce, Sam's former stepmother the late Nelle Benson, Sam's former parole officer Dolores Maloney, the late Peter August, and music producer Linc Brown before Sidwell's return over a week later on December 17.Crimes Committed[]
- Targeted Sam McCall and her family and friends [Jan 2, 2020-Aug 11, 2020, revealed on Feb 5, 2020]
- Targeted Sonny Corinthos and his family and friends [Jan 7, 2020-Jun 16, 2021; revealed on Feb 4, 2020]
- Responsible for one of Sonny's trucks being hijacked and eventually torched [Jan 7, 2020]
- Responsible for three separate shootouts in revenge for Cesar Faison, Hank Archer aka Shiloh, and Cassandra Pierce leaving Ric Lansing and Shawn Butler unharmed along with Sam McCall and Franco Baldwin (the one at the warehouse, the one on the pier, and the one in a Brooklyn pub) [Jan 29-30, 2020]
- Somehow got himself transferred from Thompson Penitentiary to Pentonville Penitentiary [revealed on Feb 5, 2020]
- Had his henchman Franco Walker pose as a rideshare driver to kidnap his great nephew Cameron Webber and Trina Robinson in revenge for Faison, Shiloh, and Cassandra [Feb 26-28, 2020]
- Illegally adopted Britt Westbourne as his new daughter after the death of Cesar Faison and the imprisonment of Liesl Obrecht [Sep 3, 2020]
- Antagonized Alexis Davis just like Nelle Benson who antagonized Sam one year earlier prior [Nov 19, 2020]
- Had Julian blow up the Floating Rib in an attempt to kill Jason, killing Dev Cerci and Dustin Phillips and nearly killing Jason, Danny Morgan, Dante Falconeri, Lulu Spencer, Franco Baldwin, Elizabeth Webber, his great nephew Cameron Webber, and many more in revenge for Faison, Shiloh, Cassandra, and Nelle [Nov 20-23, 2020]
- Conspiracy; helped Peter to frame Jason for Franco Baldwin's murder in revenge for Faison, Shiloh, Cassandra, and Nelle as Cyrus adopted Peter as his new son [Mar 17-Jun 1, 2021; Jason was arrested on Mar 17, 2021 and was exonerated on Jun 4, 2021; Cyrus was arrested on Jun 4, 2021]
- Ordered Trent Beech and Carl Pine to kill Dr. Britt Westbourne with a lethal dose and make it look like an overdose in revenge for Cesar Faison, Shiloh, Cassandra Pierce, Nelle Benson, and Sam's former parole officer Dolores Maloney [May 3, 2021; his men failed and Britt escaped with Jason]
- Ordered Carl to kill Britt and Jason as they were escaping in revenge for Faison, Shiloh, Cassandra Pierce, Nelle Benson, and Sam's former parole officer Dolores Maloney [May 3, 2021; they were saved by Brick]
- Stabbed and killed Trent for failing to kill Britt and Jason [May 4, 2021; he was later threatened behind his back by Britt's biological mother Liesl Obrecht in the aftermath]
- Illegally adopted Peter August as his new son after the deaths of Cesar Faison and Alex Devane [Mar 17, 2021]
- Threatened to "stop" his nephew Nikolas if Nikolas didn't back down from his plans to privatize Pentonville [May 19, 2021]
- Had Peter kidnap Gladys and held her hostage [May 24-26, 2021; arrested]
- Tried to have Brando kill Gladys or else he'd kill Sasha and their unborn child [May 25, 2021; Brando disobeyed; arrested]
- Held Brando at gunpoint and almost killed him after Brando disobeyed his orders [May 26, 2021; arrested]
- Indirectly responsible for Gladys getting shot in the shoulder by one of his men [May 26, 2021; arrested]
- Held Damian Spinelli hostage at gunpoint and threatened to mutilate him in revenge for the late Cesar Faison, the late Shiloh, the late Cassandra Pierce, the late Nelle Benson, and Sam's former parole officer Dolores Maloney [May 26-28, 2021; as Cesar Faison; arrested]
- Tried to shoot Jason during a shootout [May 28, 2021; as Cesar Faison; arrested]
- Fugitive; being hunted by the PCPD [May 28-Jun 4, 2021; as Cesar Faison]
- Broke into Portia Robinson's home after he escaped, fled the scene, and eluded Jason and Dante [May 28, 2021; arrested]
- Held Portia and her daughter Trina hostage at gunpoint in their own home in revenge for Faison, Shiloh, Cassandra, Nelle, and Dolores [May 28-Jun 3, 2021; as Cesar Faison; arrested]
- Forcefully grabbed Trina at gunpoint when he heard Taggert outside in revenge for Faison [Jun 3, 2021; as Cesar Faison; arrested]
- Held Laura hostage at gunpoint after Laura offered herself up for Portia and Trina [Jun 3-4, 2021; as Cesar Faison; arrested]
- Blackmailed Laura into letting him remain a free man or else he'll make sure that neither one of them makes it out of the hostage situation alive [Jun 3-4, 2021; as Cesar Faison; arrested]
- Ordered Curtis Ashford to put his gun down or else Laura would die [Jun 4, 2021; as Cesar Faison; arrested]
- Shot Curtis Ashford the stomach after making him drop his gun by threatening Laura [Jun 4, 2021; as Cesar Faison; arrested]
- Tried to blackmail Carly Corinthos into intervening on his behalf and preventing him from going to a maximum security prison by threatening to tell the feds that she and the Corinthos family kept Dev in the country illegally [Jun 10, 2021; failed; Carly revealed that she worked out an immunity deal for everyone who knew the truth about Dev]
- Ordered a hit on Laura and his full brother Martin Grey [Aug 20, 2021; revealed Aug 23, 2021]
- Suspected in Liesl Obrecht's disappearance [Aug 31, 2021; denied any involvement and had an alibi]
- Conspired with Mr. Buscema to take down Jason and Carly while Drew Cain was held captive in Compound Prison in Crete, Greece [revealed Aug 31-Sep 17, 2021; failed]
- Acquired a contraband cell phone from some of his contacts [revealed on Nov 30, 2021]
- Hired a woman to pretend to be a cleaning lady in order to find Laura and Martin in revenge for Peter August [revealed on Dec 6, 2021]
- Indirectly responsible for Martin being strangled by the woman in revenge for Peter August [Dec 8-9, 2021]
- Threatened Victor Cassadine if he came after his family again [Dec 2, 2022]
- Had Mason Gatlin kidnap his nephew Nikolas Cassadine and hold him hostage on life support [Feb 13, 2023; revealed on Mar 1, 2023; Cyrus was revealed to be the boss on Aug 22, 2023]
- Gave a shiv to Drew Cain hidden in a Bible after becoming friends with Judge Albert Kim who is like former Judge Naomi Carson [Jul 3, 2023]
- Blackmailed Austin Gatlin-Holt for Gordon Stevens' death before Jack Brennan comes to Port Charles on the first day of December [Nov 15-17, 2023]
- Became a serial killer [Aug 2024-present]
- Murdered a patient named Sylvie Mullen by overdosing her IV with digitalis [Aug 2024; revealed on Dec 30, 2024]
- Murdered Sam McCall by overdosing her IV with digitalis in revenge for the late Cesar Faison, the late Hank Archer aka "Shiloh", the late Cassandra Pierce, Sam's former stepmother the late Nelle Benson, Sam's former parole officer Dolores Maloney, the late Peter August, and music producer Linc Brown [Oct 30, 2024; revealed on Dec 9, 2024]
- Framing Elizabeth Webber for all the murders he committed via digitalis overdoses [Aug 2024-present; revealed on Dec 30, 2024]
- Stabbed Dex Heller in the back in revenge for his former henchman Mason Gatlin and henchwoman Betty Rutherford [Dec 10, 2024]
- Murdered Dex by overdosing his IV with digitalis in revenge for his former henchman Mason Gatlin and henchwoman Betty Rutherford [Dec 12-13, 2024; revealed on Dec 16, 2024]
- Injected Michael Corinthos' IV with digitalis in revenge for the late Hank Archer aka "Shiloh" [Jan 10, 2024]
Health and Vitals[]
- Assaulted and pinned against a door by his nephew Nikolas Cassadine [Apr 5, 2021]
- Threatened behind his back by Britt's biological mother Liesl Obrecht [May 4, 2021]
- Almost had a shot lined up on him by his nephew Nikolas [May 27, 2021]
- Shot in the shoulder by Jason during a shootout [May 28, 2021]
- Shot in the leg by Jordan Ashford in defense of Curtis and Laura [Jun 4, 2021]
- Threatened by Jordan's enemy Victor Cassadine [Dec 2, 2022]
- Threatened by Victor Cassadine [Dec 2, 2022]
- Threatened by Victor again [Dec 7, 2022]
- Threatened by Drew Cain after The Hook attacks who was later revealed to be Heather Webber, the death and memorial service of the late former Head Nurse Epiphany Johnson, Linc Brown's arrest, and the death of Victor Cassadine [Jul 3, 2023]
- Slammed against a wall and threatened by Steve Book [Jul 31, 2023; saved by Drew]
- Nearly assaulted with a knife by Steve Brook [Jul 31, 2023]
- Collapsed from having a heart attack and seeing a white light [Jul 31-Aug 1, 2023; saved by Drew and hospitalized on Aug 2, 2023]
Relationships[]
- Wyatt Chamberlain - Cyrus' grandfather (deceased)
- Ace Cassadine - Cyrus' great nephew and Nikolas' son with the late Esme Prince
- Charlotte Cassadine - Cyrus' great niece and Lulu's daughter with Valentin
- Nikolas Cassadine - Cyrus' nephew and Laura's son
- Spencer Cassadine - Cyrus' great nephew and Nikolas' son with Courtney (presumed deceased)
- Kevin Collins - Cyrus' brother-in-law
- Laura Collins - Cyrus' paternal half-sister
- Rocco Falconeri - Cyrus' great nephew and Lulu's son with Dante
- Andrew Grey - Cyrus' son
- Florence Grey - Cyrus' mother
- Gordon Grey - Cyrus' father (deceased)
- Liz Grey - Cyrus' daughter
- Martin Grey - Cyrus' brother
- Esme Prince - Cyrus' niece by marriage of Laura and Kevin (presumed deceased)
- Lulu Spencer - Cyrus' niece and Laura's daughter
- Aiden Spencer - Cyrus' great nephew
- Cameron Webber - Cyrus' adopted great-nephew
- Zahra Amir - Cyrus' current attorney
- Frank Anderson - (imprisoned)
- Hank Archer - aka "Shiloh" (deceased)
- Peter August - Cyrus' former associate and the late Nelle Benson's male counterpart (deceased)
- Greg Barnes - (imprisoned)
- Trent Beech - Cyrus' henchman (deceased)
- Nelle Benson - Cyrus' henchwoman, his brother Martin Grey's former client, and the late Sam McCall's former stepmother (deceased)
- Bart Bentley
- Linc Brown - His brother Martin's client, Cyrus' new friend/younger counterpart, and music producer (captured)
- Cassandra Bryant - Cyrus' friend who was hired by Cyrus before her resignation due to her activities with Cyrus
- Gabriel Burke
- Sienna Colby - Cyrus' former henchwoman
- Suzanne Cottle - Cyrus' henchwoman
- Oliver De Leon
- Sonny Faison
- Paul Ferner - Administrator of Turning Woods Long Term Memory Care
- Brock Garrison - Cyrus' henchman (deceased)
- Mason Gatlin - Cyrus' henchman (imprisoned)
- Chris Gentry - (imprisoned)
- Mallory Gentry - Cyrus' former attorney
- Paul Gentry - (imprisoned)
- Jerome Grisham
- David Hopkins - (captured)
- Marie Hopkins - His associate Peter's henchwoman and Cyrus' possible henchwoman, aka Chloe Jennings (deceased)
- Paul Hornsby - Cyrus' friend and former cellmate, former District Attorney, now Johnny's cellmate (imprisoned)
- Ron Jarrett - Court judge
- Gabriel Jenkins - Cyrus' henchman
- Albert Kim - Court judge and Cyrus' friend
- Warren Kirk - (deceased)
- Dolores Maloney - His late henchman Jeffrey Maloney's sister, Cyrus' henchwoman, the late Nelle Benson and the late Julian Jerome's friend, and the late Sam McCall's former parole officer
- Jeffrey Maloney - His henchwoman/the late Sam McCall's former parole officer Dolores Maloney's brother and Cyrus' African-American henchman - (deceased)
- Damon Montague - Cyrus' new friend and ally (captured)
- Dean Murdock - Cyrus' former attorney
- Jeffrey Nash - Cyrus' former attorney
- Cassandra Pierce - Cyrus' female counterpart (deceased)
- Carl Pine - Cyrus' African-American henchman (deceased)
- Coleman Ratcliffe
- Eli Reardon
- Jenz Sidwell - Cyrus' bald warlord counterpart
- Edward Sinclair - Court judge and Cyrus' friend and ally
- Elaine Smith - Private investigator
- Hank Smith - Cyrus' former attorney
- Elena Soto
- Suzanne Stanwyck
- Erich Sydney
- Franco Walker - Cyrus' former henchman/associate (deceased)
- Elisha Adams - Officer of the Port Charles Police Department
- Haley Adams
- Leah Adams
- Owen Anderson - The late Sam McCall's former parole officer who is much friendlier than Dolores Maloney
- Randy Ashcroft - Sheriff of the Eerie County Sheriff's Department
- Curtis Ashford - Trina's father
- Jordan Ashford - Former Commissioner of the Port Charles Police Department and current Deputy Mayor of Port Charles
- Marshall Ashford - Curtis' father and Trina's grandfather
- T.J. Ashford
- Franco Baldwin - Cyrus' enemy, former criminal, former Art Therapist at General Hospital, the late Esme Prince's maternal half-brother; and stepfather to Cameron, Aiden, and Jake Webber (deceased)
- Hayden Barnes - Cyrus' new enemy, the late Franco Baldwin's female counterpart/sister-in-law; and aunt to Cameron, Aiden, and Jake Webber
- Cody Bell
- Brick
- Steve Book - (imprisoned)
- Jack Brennan - Cyrus and his former henchman Mason's Australian counterpart and head of the W.S.B. Port Charles Field Office
- Shawn Butler - Former owner and publisher of The Invader now living in San Francisco
- Mitch Carson - The late Nelle Benson's former parole officer
- Naomi Carson
- Victor Cassadine - Valentin Cassadine's father, Donald and Charlotte Cassadine's paternal grandfather, Nikolas Cassadine's great uncle, Ava Jerome's ex-great uncle-in-law, and the late Spencer Cassadine and Ace Cassadine's great-great uncle (deceased)
- Dev Cerci - (deceased)
- Harrison Chase - Detective of the Port Charles Police Department
- Brad Cooper - Former lab manager and current lab technician at General Hospital, the late Britt Westbourne's best friend, and former gambling manager for Selina Wu at The Savoy after the death of Britt Westbourne via "The Hook" aka Heather Webber
- Brando Corbin - (deceased)
- Gladys Corbin - Cyrus' former henchwoman and his successor Damon Montague's former henchwoman after Gladys left town
- Mike Corbin - (deceased)
- Sasha Corbin
- Michael Corinthos - Lulu's adoptive ex-brother-in-law
- Sonny Corinthos - Dante Falconeri's father, Michael Corinthos' adoptive father, Rocco Falconeri's paternal grandfather, and the late Spencer Cassadine's uncle
- Willow Corinthos
- Anna Devane - Current Commissioner of the Port Charles Police Department
- Alexis Davis - Former District Attorney and Heather's cellmate (imprisoned)
- Kristina Davis - Sonny's daughter with Alexis
- Nicolas Dean - FBI agent
- Tony DiMarco
- Dante Falconeri - Cyrus' ex-nephew-in-law, Lulu's ex-husband, and Rocco's father
- Hamilton Finn
- Austin Gatlin-Holt - (deceased)
- Brent Green
- Dex Heller - (deceased)
- Stella Henry - Curtis' maternal aunt
- Jasper "Jax" Jacks
- Josslyn Jacks
- Lauren Jackson
- Ava Jerome - The late Julian Jerome's paternal half-sister now the last known living and sole surviving child of the late Victor Jerome
- Lucas Jones - The late Julian Jerome's son, Ava Jerome's nephew, and the late Sam McCall's paternal half brother
- Maxie Jones
- Paul Kelly - Officer of the Port Charles Police Department
- Molly Lansing-Davis - Ric's only daughter with Alexis, Sonny's niece, and Assistant District Attorney
- Ric Lansing - Former District Attorney, Sonny's maternal half-brother, and Cyrus' soon-to-be new defense attorney
- Richard Lowe - Court judge
- Bob Massicotte - (deceased)
- Shane McAvoy - Johnny Zacchara's new attorney
- Sam McCall - The late Julian Jerome's daughter with Alexis Davis and Lucas Jones' paternal half sister (deceased)
- Keith Miller
- Sally Miller
- Wayne Miller
- Danny Morgan - Jason Morgan and the late Sam McCall's son
- Jason Morgan
- Liesl Obrecht - The late Britt Westbourne's biological mother
- Dustin Phillips - (deceased)
- Diana Prince - aka Wonder Woman
- Brook Lynn Quartermaine
- Drew Quartermaine - Former Navy SEAL
- Monica Quartermaine - Former Chief of Staff at General Hospital, Jason's adoptive mother, and Michael's biological grandmother, and Wiley's great-grandmother
- Ned Quartermaine - Former Mayor of Port Charles
- Olivia Quartermaine - Rocco's paternal grandmother
- Scout Quartermaine - The late Sam McCalll's daughter with Drew Quartermaine
- Wiley Quartermaine-Conthinos - Sonny Corinthos and Carly Spencer's grandson, Michael Corinthos' son with the late Nelle Benson, and Monica Quartermaine's great-grandson
- Zoe Raleigh
- Portia Robinson - Trina's mother
- Trina Robinson - Curtis and Portia's daughter
- James Scorpio - Anna and Robert's son and Detective of the Port Charles Police Department
- Mac Scorpio - Former Commissioner and current Chief of Detectives of the Port Charles Police Department
- Robert Scorpio - Former Commissioner of the Port Charles Police Department, former WSB agent, and current District Attorney
- Steven Scott - Brad's parole and probation officer
- Ellen Scully - Officer of the Port Charles Police Department
- Jim Searcy - Officer of the Port Charles Police Department
- Diane Seaton
- Jenz Sidwell - Warlord and owner of Wyndemere Castle
- Mark Simon - (deceased)
- Carly Spencer - Former editor in-chief at Crimson Magazine
- Damian Spinelli - Private investigator
- Marcus Taggert
- Wayne Vickers - Court judge
- Elizabeth Webber - His great nephew Cameron's mother
- Heather Webber - aka "The Hook" killer best known to conceal her face and identity for most of 2022 until New Year's Eve 2023, the late Esme Prince's biological mother, Ace Cassadine's maternal grandmother, and Alexis Davis' cellmate (imprisoned)
- Lesley Webber - Laura's mother; Nikolas Cassadine, Lucky Spencer, and Lulu Spencer grandmother; and the late Spencer, Ace, and Charlotte Cassadine, and Aiden Webber's great-grandmother
- Mary Wells - Current Head Nurse at General Hospital
- Britt Westbourne - Former Chief of Staff at General Hospital (deceased)
- Darryl Williams - Officer of the Port Charles Police Department
- Johnny Zacchara - Cyrus' enemy and Sonny and Jason's new ally (imprisoned)
- Zatanna Zatara