Ava Jerome is a fictional character on the ABC daytime soap opera General Hospital. She is the daughter of the late mob boss Victor Jerome and his ex-mistress Ryan's Hope alum character Delia Ryan Coleridge. As of 2024, Ava is currently the last known living and sole surviving child of Victor Jerome.
She had been portrayed by actress Maura West since the character's debut on May 8, 2013.
She was portrayed by Kimberly McCullough disguised as Sonny's longtime best friend Robin Scorpio-Drake from November to December 22, 2015 after the real Robin was rescued.
On January 17, 2018; Ava had her own episode devoted to her before Anders Hove returned as Cesar Faison two days later on January 19 until February 1.
Development[]
Introduction[]
Ava answers the door and Luke Spencer introduces himself. Ava reveals that she is the mother of Lauren Frank and tells Luke the story of she and Franco met and he had a charming side. After they knew that she was pregnant, she realized that Franco had a darker side and wanted to keep Lauren away from it. Luke lets Ava know that Franco is biologically a Quartermaine, and Lauren is entitled to shares of the family company, ELQ.
He gives her a proxy statement to hand over to Lauren, signing in favor of Tracy Quartermaine. Luke leaves and Morgan Corinthos walks down the staircase. Morgan ran to Ava's house when the people who he owed money threatened to come after him. It's later revealed that Morgan is dating her daughter, Kiki (later revealed to be short for Lauren Katherine Jerome).
In 2018, her daughter Kiki was murdered by Ryan Chamberlain who was revealed to be alive 23 years later.
From 2020-23, she was married to Prince Nikolas Cassadine.
Storylines[]
Ava and Kiki talk about the situation with Morgan while Robin Scorpio-Drake is being held against her will by Sonny Corinthos' enemies overseas after The Nurses' Ball. Ava convinces Kiki to go to Port Charles to be with Morgan, and she soon comes too. She tracks down Tracy, and tells her she will get her daughter to sign over her shares in exchange for a large sum of money. Tracy agrees, wanting control of ELQ. Ava tells Kiki that her father is the serial killer Franco and that he is the twin brother of Jason Morgan and also the grandson of late Edward Quartermaine, which entitles Kiki to a piece of the shares of the company ELQ. Ava tries to get Kiki to sign over her shares, but Kiki angrily disagrees to sign when Ava reveals she was bribed into getting Kiki's signature. Ava also meets Duke Lavery, when Ava goes to ELQ to talk to A.J. Quartermaine, and they have a conversation about her surname of Jerome. Duke has a past with the Jerome mob family.
Franco is revealed to be alive, and Ava tries to keep him away from Kiki. However, Kiki eventually comes to the Quartermaine house, where Franco is, and ends up moving in, along with Morgan. Ava tries to blackmail Franco into leaving Kiki alone by revealing that she knows Franco was the one who poisoned the ELQ relish just like Jerry Jacks who poisoned the water supply who is keeping Robin captive making Robin be replaced by Jerry and Obrecht's newest accomplice Brad Cooper. It's revealed that Ava was the one who shot Olivia Falconeri in a botched attempt to kill Franco. Ava agrees to let Franco have a relationship with Kiki, while Franco agrees to help Ava take over ELQ using his shares. The two move into the Quartermaine mansion, pretending to be a couple.
Ava on the witness stand testifying for the lawsuit against Mayor Janice Lomax in civil court
In 2016, Ava's daughter Kiki is shot and Ava allows Avery to stay with Sonny while Kiki recovers. Ava was in civil court in a lawsuit against Mayor Janice Lomax who violated her constitutional rights along with everybody else except T.J. Ashford and former Head Nurse Epiphany Johnson with judge James Horowitz presiding as Ava is with the American Civil Liberties Union. After Kiki recovered Ava wanted to bring Avery home but was blackmailed by Carly and Paul Hornsby. She then goes and please with Sonny and he agrees to give her limited visitation with Avery. A few months later during one of her visits with Avery Ava goes upstairs and switches Morgan's lithium with placebo's. That lead Morgan getting killed due to him stealing Julian's car and the car blew up from a bomb planted by Olivia Jerome.
Throughout the rest of the year, Ava guilty conscience kept getting to her. At the Nurses' Ball 2017, Sonny and Carly found out what Ava did and they cornered Ava and she throws something causing a fire which then backfired when she is trapped in the fire suffering third degree burns. While she in the hospital Sonny takes away all her rights to her daughter Avery. Ava eventually forms a friendship with Griffin Munro which leads to romance. Valentin Cassadine makes a deal that Ava won't testify against him, after witnessing him kill Nikolas and be replaced by his own children Donald and Charlotte Cassadine, if he tells her where to get her face repaired because Valentin had the Magic Milo performances discontinued because he wanted to ensure his children's safety. Ava eventually agrees and is sent to a Russian clinic where Dr. Richard Klein does the initial repairs to her face. She escapes with Patient 6 and still needs a second surgery to complete her face. Before Dr. Klein leaves town, he gives Ava a flash drive with his work on repairing facial scars before he was revealed to be working with Cesar Faison as Faison's henchman. She gives it to sketchy Dr. Zajac who almost goes through with the procedure before Griffin stops him. Griffin agrees to use the drive and completes Ava's facial reparation himself. During their romance, Ava tries to be a better person. But some of her true colors come out when Mike, Avery's grandfather who suffering from dementia, took off with Avery. Ava demands joint custody of Avery or she will press charges on Mike. Sonny relents and Griffin disgusted by it. Griffin tension with escalates at the 2018 Nurses' ball which lead to Ava dumping Griffin. Griffin then sleeps with Kiki. Ava begs for forgiveness the next day which he does but doesn't tell her he had sex with Kiki.
Ava finds out in court on Kiki's trial after Franco accidentally texted the info to her. She pulled Scott to the side and demands he makes Griffin admit he had sex with Kiki. When he does Ava slaps Griffin twice vowing to make him pay which leads to her getting him suspended from the hospital and getting him barred from returning to preaching. She also disowns Kiki calling her a liar, traitor and a whore!! Later Kiki slapped Ava after finding out about Ava getting Griffin barred from priesthood. After some convincing from Julian, Ava went over to Kiki's house to apologize but finds Griffin there and goes off on both of them. She then once again disowns Kiki and now currently considering her an enemy who needs to pay the price!!!!!!
In October, Ava began a romantic relationship with Ryan Chamberlain thinking he is Kevin Collins.
On November 26, Kiki was found stabbed to death in the Haunted Star and Ava is left distraught. After Griffin is arrested for her murder, Ava tries to kill him at the PCPD only to be stopped by Julian and Ryan.
On December 6, Ava meets her great uncle-in-law Victor Cassadine.
On July 17, it is revealed that Ava is unharmed after James Gunn shot Curtis at the Metro Court Pool.
On February 21, Ava meets Selina Wu after she came into Sonny's apartment.
On July 1, Ava meets the new editor-in-chief of The Invader as they are on friendlier terms with each other as Ava thinks of Adrian is much friendlier than her late ex-stepson Spencer.
On July 10, Ava asked pharmacist Clement Moore to replace Sonny's bi-polar medication with placebos without letting the Chief of Staff Portia Robinson knowing.
On August 13, Ava is with FBI agent John Cates and Scott Baldwin after Ava was released on bail. At the same time after Scott left, Ava and John sees Jack Brennan who was released from prison as Ava asked who that man is thinking that Jack is Mason's Australian counterpart. Ava and Cates are plotting that Clark Clement is in their hands because Cates is saying to Ava that Clement will be on their side.Crimes Committed[]
- Ran an illegal online gambling ring and knowingly lured Morgan Corinthos into a gambling debt with Julian Jerome in which Jason Morgan would not have liked if he were still around [pre−Apr 2013]
- Obstruction of justice; knows that Paul Hornsby went after Sonny under Jerry Jacks' orders and is keeping quiet about it [Sep 22, 2015-present]
- Conspiracy; helped Jerry Jacks, Paul Hornsby, Faison's son Sonny, Franco Baldwin, and Johnny Zacchara hold Robin Scorpio-Drake against her will at Cassadine Island to keep her away from Port Charles, Sonny, her friends and family [revealed Nov 2015-December 22, 2015; as Robin Scorpio-Drake]
- Withholding the information that Nikolas had Hayden Barnes shot back in 2015 where Naomi Carson gained Ray Giles, Nikolas Cassadine, and Epiphany Johnson as her new friends [revealed Dec 9, 2021-present]
- Held Ryan Chamberlain at gunpoint and threatened to kill him [Feb 21-22, 2023]
- Spied on Sonny for Nikolas' uncle Cyrus Renault after the death and will reading of Victor Cassadine in which her daughter Avery Jerome-Corinthos did not attend [Jul 2023]
- Hiding from Sonny that his dosage had been tampered with in revenge for the late Victor Cassadine [May 2024-present]
- Conspiring to sabotage Sonny's custody of their daughter Avery in revenge for the late Victor Cassadine [Jul 10, 2024-present; placebo replacement discovered Aug 7, 2024]
- Blackmailed Clement Moore to replace Sonny's bi-polar medication with placebos in revenge for the late Victor Cassadine [Jul 10, 2024-present]
- Lied to the police about Kristina tripping on shoes instead of Cates' bag [Aug 2, 2024]
- Charged with assault of Kristina and manslaughter of her surrogate baby. [Aug 6, 2024]
Health and Vitals[]
- Choked by A.J. Quartermaine [Mar 4, 2014]
- Threatened by Carlos Rivera [Apr 21, 2014]
- Held at gunpoint and almost killed by her brother Julian Jerome [May 2-5, 2014]
- Held at gunpoint and almost killed by Sonny Corinthos [May 29-30, 2014]
- Held prisoner at Sonny's house [Jun 6-Jul 24, 2014]
- Had a glass of water thrown at her face by her mother [Jul 7, 2014]
- Held at gunpoint and threatened by Mickey Diamond [Jul 24, 2014]
- Held at gunpoint by Mickey for a second time [Jul 25, 2014]
- Experienced Braxton Hicks contractions [Sep 11, 2014]
- Had her Nifedipine switched out for Misoprostol, a medication that causes miscarriage/preterm labor, by Sabrina Santiago [revealed Sep 18, 2014]
- Almost kidnapped by Sonny's men [Sep 22-23, 2014]
- Became a nervous wreck after running over Jason Morgan just when she thought she and Julian were rid of him [Sep 24, 2014]
- Experienced more Braxton Hicks contractions after the death of Victor Cassadine [Oct 8, 2014]
- Went into premature labor as a result of taking pills given to her by Sabrina Santiago, but it was stopped [Oct 16, 2014]
- Was given a shot of terbutaline to stop her labor [Oct 20, 2014]
- Paralyzed [Oct 31, 2014]
- Injected with a drug by Nina Reeves that caused her to go into premature labor again [Oct 31, 2014; shown on Nov 3, 2014]
- Tried to crawl out of the Brownstone; failed [Oct 31, 2014; shown on Nov 3, 2014]
- Gave birth to her premature daughter, Avery completely natural [Oct 31, 2014; shown on Nov 4, 2014]
- Held at gunpoint and almost killed by Sonny again but Michael stopped him [Nov 6, 2014]
- Unable to walk straight after giving birth and collapsed [Nov 7, 2014]
- Held at knifepoint, threatened, and almost killed by a prison guard [Jan 23, 2015]
- Threatened and almost killed by a prison guard again [Jan 29, 2015]
- Rendered unconscious in a car accident caused by Johnny Zacchara and Carlos Rivera under Luke's orders [Jan 30, 2015]
- Held at gunpoint by Carlos Rivera [Feb 2-3, 2015]
- Shot in the shoulder by Carlos [Feb 3, 2015]
- Knocked off a bridge by Carlos after getting shot [Feb 3, 2015]
- Left hanging off a bridge by Carlos and then Sonny tried to rescue her, but failed causing Ava to fall [Feb 3, 2015]
- Presumed dead [Feb 3-26, 2015]
- Had terminal leukemia, but received a life saving bone morrow transplant from her daughter, Avery; in remission [terminal leukemia revealed Mar 9, 2015; transplant performed Apr 2015; transplant revealed Jun 3-4, 2015]
- Her DNA was slightly altered by the transplant [revealed May 27, 2015]
- Burned her fingerprints off [revealed May 27, 2015]
- Attacked and threatened by Nina Reeves [Aug 13, 2015]
- Framed by Nina for the murder of Silas Clay [Aug 25-31, 2015]
- Threatened by Sonny again [Oct 7, 2015]
- Manhandled by Sonny after she antagonized him (he tightly grabbed her wrist and wouldn't let go) while the real Robin Scorpio-Drake is held against her will by Sonny's enemies [Nov 9-10, 2015; as Robin Scorpio-Drake]
- Held hostage at gunpoint in a chapel-full of people by Landon Dixon under orders of Mayor Janice Lomax in revenge for the late Kyle Sloane and the late Helena Cassadine and her constitutional rights were violated by Mayor Janice Lomax [Feb 19, 2016; shown from Feb 23-24, 2016; then came the will read of Helena Cassadine at Wyndemere later]
- Offered herself up as a hostage to protect the Davis girls [Feb 19, 2016; shown on Feb 24, 2016]
- Cursed under the spirit of the late Helena Cassadine [Feb 19, 2016; shown from Feb 23-24, 2016]
- Blackmailed by Carly into giving up Avery (with a sex tape) [May-Jun 2016; it worked]
- Threatened by Sonny if she messed with Morgan again [Jun 8, 2016]
- Locked in a room (along with Nikolas Cassadine) by Huxley Lynch before Huxley was replaced by Valentin Cassadine a month later [Jun 2016]
- Got shot by taser stun gun [Jun 23, 2016]
- Held hostage at gunpoint in a room of people on Cassadine Island by Valentin Cassadine (aka Theo Hart) [Jul 15-26, 2016; not even Paul Hornsby stop him and rescue them as District Attorney because he has no jurisdiction there]
- Taken hostage at gunpoint by Valentin and almost got shot by him [Jul 19, 2016]
- Threatened with a gun by Valentin Cassadine multiple times [Jul 22, 2016]
- Was exposed to malaria [revealed Aug 9, 2016]
- Held at gunpoint by Sonny and almost killed [Feb 9-10, 2017]
- Held hostage at gunpoint, and was tied up, in her own apartment by her sister, Olivia Jerome [Mar 10, 2017; the armed robbers Chris and Paul Gentry returned the favor to her nearly three weeks later on Mar 29-30]
- Held hostage at gunpoint at the Floating Rib by Chris and Paul Gentry demanding her and others in the room, including Ned Quartermaine, Olivia Falconeri, and Lucy Coe, to hand over their belongings under Valentin Cassadine's orders in revenge for the imprisoned Olivia Jerome returning the favor to her nearly three weeks later [Mar 29-30, 2017]
- Trapped in a warehouse (along with Sonny and Carly) that she lit on fire by throwing a lantern on the ground [May 26-30, 2017]
- Suffered from smoke inhalation [May 30, 2017]
- Suffered from second and third degree burns over 50% of her body in the fire [May 30, 2017; revealed May 31, 2017]
- Flatlined (but was brought back) [Jun 8, 2017]
- Was grabbed tightly by the wrist by Patient 6, suffered from mild pain as a result [Sep 19, 2017]
- Held hostage at gunpoint during Drew and Sam’s party at the Metro Court by two suspects in revenge for Cesar Faison and were both later arrested, pleaded guilty, and sentenced to life in prison with no possibility of parole by Judge Natalie Rawles [Oct 26-27, 2017; saved by Sonny leaving Dante's partner Nathan West and Art Therapist Franco Baldwin unharmed, not even Ric Lansing nor Shawn Butler could rescue her and the others leaving Mayor Janice Lomax outraged]
- Had a nasty laceration on her temple following the earthquake one month after the deaths of Cesar Faison and Nathan West [Mar 5, 2018]
- Tossed off a bridge by Ryan Chamberlain [Mar 8, 2019; caught by Jason]
- Emotionally destroyed after finding out that she was with Ryan (not Kevin Collins) for the past six months and that Ryan killed Kiki [Mar 11, 2019]
- Threatened with a knife by Ryan [May 23, 2019]
- Stalked by Nikolas [Oct 17-31, 2019; revealed Oct 31, 2019]
- Passed out after Nikolas revealed himself to her [Nov 1, 2019]
- Checked herself into Shadybrook Sanitarium with the help of Laura Collins and Julian after having a mental breakdown caused by alcohol and Nikolas' return [Nov 1-Dec 9, 2019]
- Tossed off a balcony by Valentin and into the river below over the Cassadine Codicil [Jan 2, 2020]
- Briefly held at gunpoint by Nikolas [Jan 8, 2020; he never intended on killing her]
- Had a snake put in her purse by Nikolas' niece/cousin Charlotte Cassadine who was being like her late grandmother Helena Cassadine [Apr 16, 2020]
- Had a portrait of her made by Franco Baldwin vandalized by Nikolas [Aug 14, 2020; revealed on Aug 17, 2020 after Dolores Maloney is no longer Sam McCall's parole officer]
- Stalked to her cabin by Nikolas [Sep 15, 2020]
- Blackmailed by Ryan into paying him a visit at Pentonville Penitentiary [Oct 5, 2020]
- Blackmailed by Ryan into paying him a visit every week and into divorcing Nikolas [Oct 6-Nov 4, 2020]
- Threatened by Ryan [Oct 30, 2020]
- Stalked and harassed by Spencer Cassadine and Esme Prince who manipulated Spencer into sending creepy gifts and messages in order to break her and Nikolas up under Ryan's orders [Feb 19-Oct 1, 2021; Spencer's involvement revealed on Jul 1, 2021; Esme's involvement revealed on Aug 19, 2021; Ryan's involvement revealed on Mar 9, 2022]
- Stalked by Esme Prince under her father Ryan Chamberlain and Nikolas' great uncle Victor Cassadine's orders [Aug 16, 2021]
- Had her car torched by Esme, who placed Kiki's stolen hospital badge beside it [Aug 17, 2021]
- Stabbed in the stomach by The Hook with a hook [Aug 26, 2022; hospitalized on Aug 29, 2022 and the Hook was later revealed to be Esme's biological mother Heather Webber on New Year's Eve 2022]
- Blackmailed into spying on Sonny for the Unnamed Female Mob Boss by Mason Gatlin or her role in Nikolas' "death" would be made public [Jul 2023-Nov 2023]
- Grazed on her hand by the bullet of an Ron Gallo putting her daughter Avery Jerome-Corinthos in the line of fire the same day that Spencer Cassadine and Esme Prince were presumed deceased when Spencer and Esme were dragged into Seine River in Paris [Jan 31, 2024]
Relationships[]
- Steven Culp - Ava's nephew
- Julian Jerome - Ava's half-brother (deceased)
- Kiki Jerome - Ava's daughter with Silas (deceased)
- Olivia Jerome - Ava's half-sister (deceased)
- Victor Jerome - Ava's father (deceased)
- Avery Jerome-Corinthos - Ava's daughter with Sonny
- Sam McCall - Ava's niece
- Curtis Ashford
- Jordan Ashford - Former Commissioner of the Port Charles Police Department, current Deputy Mayor of Port Charles, and the late Eileen Ashby's successor
- James Ashton - Team Leader of the International Response Team from the Special Air Service in the United Kingdom and her former butler Edward Giles' old friend
- Franco Baldwin - (deceased)
- Scott Baldwin - Former District Attorney and the late Franco Baldwin's father
- Asher Bellamy - FBI agent
- Linda Boyle
- Drew Cain
- John Cates - FBI Special Agent, Ava's friend, ally, and ex-lover (deceased)
- Lois Chann - Court judge
- Laura Collins - Current Mayor of Port Charles, Ava's ex-mother-in-law, and Avery's ex-step grandmother
- Nicolas Dean - FBI agent
- Adrian DeWitt - Acting editor-in-chief of The Invader
- Sibley Gamble - Psychic
- Austin Gatlin-Holt - (deceased)
- Edward Giles - Ava's friend and former butler at Wyndemere Castle replacing Alfred during her ownership of Wyndemere Castle before selling Wyndemere to David Spears
- James Horowitz - Court judge
- Tara Horowitz - FBI agent
- Paul Hornsby - Ava's friend, former accomplice, former District Attorney, and Margaux's predecessor (imprisoned)
- Sarah Johnson - FBI Liaison and Crisis Negotiator of the International Response Team from the Los Angeles FBI office in the United States
- Albert Kim - Court judge
- Janice Lomax - Former Mayor of Port Charles, Valentin and Charlotte's friend and supporter, and now receptionist at The Invader
- Manrico - (imprisoned)
- Adam McCullough
- Clement Moore - Chief Pharmacist at General Hospital, Ava's friend/co-conspirator, now relocated to The Island
- Jason Morgan - Ava's ex-nephew-in-law
- Eric Moss - Ava's African-American bodyguard at the gallery
- Harriet Nekaya
- Felicia Scorpio
- David Spears - Owner of Wyndemere Castle is located on Spoon Island
- Damian Spinelli - Private investigator
- Tilda - (imprisoned)
- Waltz - (imprisoned)
- Beatrice Westbrook - Tactical Operations and Crisis Management Specialist of the International Response Team from the New York City Police Department in the United States
- James White
- Selina Wu
- Madison Yeung - The late FBI Special Agent John Cates' friend
- Mark Ambrose - Her late ex-great uncle-in-law Victor Cassadine's henchman
- Hank Archer - aka "Shiloh" who bores a striking resemblance to the late Nathan West (deceased)
- Johann Bauer - Her late ex-great uncle-in-law Victor Cassadine's henchman and the late Esme Prince's bodyguard/male counterpart
- Nelle Benson - Heather's younger counterpart, Ava's former sister-in-law, her nephew Steven's friend (deceased)
- David Boyd - Her late ex-great uncle-in-law Victor Cassadine's African-American henchman
- Jack Brennan - Former leader of Pikeman Security Group, former director of the WSB, Ellen Garten and Mason Gatlin's friend/Australian counterpart, and now head of the W.S.B. Port Charles Field Office
- Helena Cassadine - Ava's ex-grandmother-in-law and Avery's ex-step great-grandmother (deceased)
- Stavros Cassadine - Ava's ex-father-in-law and Avery's ex-step-grandfather (deceased)
- Victor Cassadine - Ava's ex-great uncle-in-law and Avery's ex-step great-great uncle (deceased)
- Ryan Chamberlain - The late Esme Prince's late father and Ace Cassadine's maternal grandfather (deceased)
- Amber Chua
- Russel Clark - Her late ex-great uncle-in-law Victor Cassadine's henchman and the late Esme Prince's male counterpart (hospitalized and later imprisoned)
- Sonny Corinthos - Her daughter Avery's father
- Gavin Crawford - Her late ex-great uncle-in-law Victor Cassadine's African-American henchman and Roz Venta's male counterpart (deceased)
- Harry DeFranco - Armed robber
- Jane Edwards - Her late ex-great uncle-in-law Victor Cassadine's henchwoman (deceased)
- Lou Evans - Ava's ex-lover and friend the late John Cates' friend and ally
- Cesar Faison - (deceased)
- Sonny Faison - The late Cesar Faison's son with an unknown woman
- Connie Falconeri - (deceased)
- Keith Fletcher - Her late ex-great uncle-in-law Victor Cassadine's henchman
- Ron Gallo - Sniper working for Pikeman Security Group who grazed Ava's hand and put her daughter Avery in the line of fire
- Mason Gatlin - The late Austin Gatlin-Holt's cousin and Jack Brennan's American counterpart (imprisoned)
- Gerard - Ava's ex-lover and friend the late John Cates' new friend overseas in Africa
- James Gunn - Sniper working for Pikeman Security Group who shot Curtis and left Ava unharmed and put Violet in the line of fire
- David Hadley - Her late ex-great uncle-in-law Victor Cassadine's henchman
- Hamish Hampton - (deceased)
- Mark Hay - Her late ex-great uncle-in-law Victor Cassadine's henchman
- The Hook - Serial killer whose face and identity are concealed and is a woman colluding with her great uncle-in-law Victor and later revealed to be the late Franco Baldwin and the late Esme Prince's biological mother Heather Webber on New Year's Eve 2022 who is unknowingly working with the True Believers because Heather was wanting revenge for the late Cesar Faison and avenging her daughter Esme before Esme's presumed death on Seine River in Paris in 2024 (captured)
- Jerry Jacks
- Elmer Lewis - Her late ex-great uncle-in-law Victor Cassadine's henchman
- Maksim - Her late ex-great uncle-in-law Victor Cassadine's henchman
- Albert Moreno - Her late ex-great uncle-in-law Victor Cassadine's auctioneer henchman
- Esme Prince - Her late ex-great uncle-in-law Victor Cassadine's female associate who was the late Spencer Cassadine's ex-girlfriend, the late Ryan Chamberlain's daughter with Heather Webber, the late Franco Baldwin's maternal half-sister, and her ex-sister-in-law Lulu Spencer's late stepcousin (presumed deceased)
- Cyrus Renault - Later revealed to be Mason and Betty's mysterious boss
- Carlos Rivera - (deceased)
- Heather Roth
- Winston Rudge - Her late sister Olivia Jerome's henchman, her late ex-great uncle-in-law Victor Cassadine and his son Valentin's associate from South Africa who bores an uncanny resemblance to Valentin (imprisoned)
- Tobias Richard - Her late ex-great uncle-in-law Victor Cassadine's henchman
- Jenz Sidwell - Ava's ex-lover and friend the late FBI Special Agent John Cates' friend, ally; and Valentin Cassadine's bald warlord counterpart
- Stone - Ultimate villain whose face, identity, and physical appearance concealed later revealed to be Valentin Cassadine just like "The Hook" killer before she was revealed to be Heather Webber
- Bill Watkins - Her late ex-great uncle-in-law Victor Cassadine's henchman
- Eric Watson - Armed robber
- Heather Webber - The late Franco Baldwin, the late Esme Prince's biological mother, and Ace Cassadine's maternal grandmother aka "The Hook"; now living in Sedona, Arizona
- Johnny Zacchara - (imprisoned)